4-hydroxy-3-methoxycinnamic acid sodium salt
Sodium Ferulate
CAS: 24276-84-4
Molecular Formula: C10H9NaO4
4-hydroxy-3-methoxycinnamic acid sodium salt - Names and Identifiers
4-hydroxy-3-methoxycinnamic acid sodium salt - Physico-chemical Properties
| Molecular Formula | C10H9NaO4 |
| Molar Mass | 216.17 |
| Boling Point | 372.3°C at 760 mmHg |
| Flash Point | 150.5°C |
| JECFA Number | 2014 |
| Solubility | H2O : 100 mg/mL (462.60 mM; Need ultrasonic);DMSO : 33.33 mg/mL (154.18 mM; Need ultra |
| Vapor Presure | 3.34E-06mmHg at 25°C |
| Appearance | Light yellow powder |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| MDL | MFCD00075727 |
| Use | For the treatment of coronary heart disease, ischemic encephalopathy, leukopenia and thrombocytopenia and other conditions |
4-hydroxy-3-methoxycinnamic acid sodium salt - Reference
| Reference Show more | 1. Cao Bo, Ci Zhimin, Xu Runchun, et al. Study on Quality Evaluation of Xiaojin Pills Based on Antiplatelet Aggregation Titer [J]. Chinese Herbal Medicine, 2020, v.51;No.664(05):168-173. 2. Zhao Yuling, Hua Fang, Li Guan, et al. Quantitative Determination of Antigel Activity of Chuanxiong and Its Chinese Patent Medicine [J]. Chinese Herbal Medicine, 2020. 3. Hua Fang, zhao Yuling, Li Guan, et al. Study on Determination of Anticoagulant Effect of Ligusticum wallichii and Its Chinese Patent Medicine [J]. Chinese Herbal Medicine, 2019, 50(07):1698-1702. 4. Yao Yixin. Study on Bioassay Methodology of Anti-platelet Aggregation Activity of Ligusticum wallichii, decoction pieces and Chinese Patent Medicine [J]. Chinese Herbal Medicine, 2017, 48(11):2249-2254. 5. Gong Wan, Chen Xiaoling, et al.. Protective effect and mechanism analysis of sodium ferulate on inflammatory injury caused by cerebral ischemia-reperfusion in rats [J]. Chinese Journal of Experimental Formulas, 2019, 25(03):102-107. 6. Xin, Pan Yuan, Xie Xiaofang, Tang Guangmei, Peng Cheng. Effects of anisodine hydrobromide on hemorheology, microcirculation and platelet aggregation [J]. Chinese patent medicine, 2020,42(09):2438-2445. 7. Qiao Mingming, Xiong Liang, Liu Yu, Guo Li, Liu Fei, Peng Cheng. Material Basis Study on Difference of Activating Blood Effect between Turmeric and Curcuma Rhizoma [J]. World Science and Technology-Modernization of Traditional Chinese Medicine, 2020,22(07):2531-2539. |
4-hydroxy-3-methoxycinnamic acid sodium salt - Standard
Authoritative Data Verified Data
This product is 3-methoxy-4-hydroxycinnamic acid sodium salt dihydrate. The content of C10H9Na04, calculated as anhydrous, shall not be less than 98.5% (for oral administration) or 99.0% (for injection).
Last Update：2024-01-02 23:10:35
4-hydroxy-3-methoxycinnamic acid sodium salt - Trait
Authoritative Data Verified Data
- This product is white or off-white crystalline or crystalline powder; Odorless.
- This product is soluble in water, very slightly soluble in ethanol, insoluble in chloroform or ether.
absorption coefficient
operation in the dark. Take this product, precision weighing, add water to dissolve and quantitatively dilute the solution containing about 10% per lml, according to UV-visible spectrophotometry (General 0401), the absorbance was measured at a wavelength of 310mn, and the absorption coefficient of C10H3NaO4 was 690 to 732.
Last Update：2022-01-01 13:32:09
4-hydroxy-3-methoxycinnamic acid sodium salt - Differential diagnosis
Authoritative Data Verified Data
- the solution under the determination of absorption coefficient has the maximum absorption at the wavelengths of 287nm and 310nm as determined by ultraviolet-visible spectrophotometry (General rule 0401), there is minimal absorption at a wavelength of 254nm.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 775).
- identification reaction of sodium salt of this product (General rule 0301).
Last Update：2022-01-01 13:32:09
4-hydroxy-3-methoxycinnamic acid sodium salt - Exam
Authoritative Data Verified Data
pH
take this product, add water to make a solution containing about 50mg per lml, check according to law (General 0631), pH value should be 6.0~7.5.
clarity and color of solution
take this product and add water to make a solution containing about 20mg per 1 ml, the solution should be clear and colorless; If the color is colored, compare with the yellow or yellow-green 2 Standard Colorimetric solution (General rule 0901 first method), not deeper (for injection).
Related substances
operation in the dark. Take this product, add mobile phase to dissolve and dilute to make a solution containing about 0.7mg per 1ml as a test solution; Take 1ml for precision measurement, put it in a 200ml measuring flask, dilute to the scale with mobile phase, as a control solution. According to high performance liquid chromatography (General rule 0512) test, silica gel bonded with eighteen alkyl silane was used as filler; Methanol-water-acetic acid (30:69:1.5) was used as mobile phase; Detection wavelength was 322nm; the number of theoretical plates shall not be less than 2000 calculated by sodium ferulate peak, and the separation degree between sodium ferulate peak and adjacent impurity peak shall meet the requirements. 10 u1 of the test solution and the control solution were respectively injected into the liquid chromatograph, and the chromatogram was recorded to 2.5 times of the retention time of the main component peak. If there are impurity peaks in the chromatogram of the test solution, the sum of each impurity peak area shall not be greater than the main peak area of the control solution (0.5%).
moisture
take this product, according to the moisture determination method (General 0832 first method 1), the moisture content should be 13.0% ~ 15.5%.
pyrogen
take this product, add Sterile Water for Injection to make a solution containing 5mg of sodium ferulate per lml, check according to law (General rule 1142), dose according to rabbit body weight per lkg slow injection of 3ml, should meet the requirements. (For injection)
sterile
take this product, dissolve it with appropriate solvent, and treat it by membrane filtration method. Check it according to law (General rule 1101). (For aseptic dispensing)
Last Update：2022-01-01 13:32:10
4-hydroxy-3-methoxycinnamic acid sodium salt - Content determination
Authoritative Data Verified Data
operation in the dark. Take about 0.15g of this product, precision weighing, add glacial acetic acid 20ml to dissolve, add acetic anhydride 3ml and crystal violet indicator solution 1 drop, with perchloric acid titration solution (0.1 mol/L) titration to the solution is blue-green, and the result of the titration is corrected with a blank test. Each 1 ml of perchloric acid titration solution (0.1 mol/L) corresponds to 21.62mg of C10H9Na04.
Last Update：2022-01-01 13:32:10
4-hydroxy-3-methoxycinnamic acid sodium salt - Category
Authoritative Data Verified Data
Anti-platelet aggregation drugs.
Last Update：2022-01-01 13:32:11
4-hydroxy-3-methoxycinnamic acid sodium salt - Storage
Authoritative Data Verified Data
light shielding, sealed storage.
Last Update：2022-01-01 13:32:11
4-hydroxy-3-methoxycinnamic acid sodium salt - SodiumFerulateTablets
Authoritative Data Verified Data
This product contains sodium ferulate (C10H9Na04 • 2H20) should be 90.0% ~ 110.0% of the label amount.
trait
This product is white or off-white.
identification
- take the solution under the item of content measurement, and take the item of sodium ferulate; Separate the item (1) Test, show the same reaction.
- This product shows the reaction of sodium salt identification (1) (General rule 0301).
examination
- the related substances were protected from light. Take an appropriate amount of fine powder of this product, add mobile phase to dissolve and dilute sodium ferulate to make a solution containing 0.7mg of sodium ferulate per 1ml as a test solution; Take 1ml for precision measurement and put it in a 200ml water bottle, dilute to the scale with the mobile phase, shake, and serve as a control solution. According to the method of sodium ferulate related substances. If there are impurity peaks in the chromatogram of the test solution, the sum of each impurity peak area shall not be greater than the main peak surface of the control solution (0.5%).
- dissolution rate shading operation. Take this product, according to the dissolution and release determination method (. Then 0931 The first method), with water as the dissolution medium, the rotation speed is 50 rpm, according to the law. After 30 minutes, the solution was filtered, and the filtrate was Diluted quantitatively with water to a solution containing about 10ug of sodium ferulate per lml. According to UV-Vis Spectrophotometry: (General 0401), the absorbance was measured at a wavelength of 3 l0nm, and the absorbance was calculated by taking the 1-yield coefficient of C10H9Na04 as 712, and multiplying the result by 1.167 to obtain the dissolution amount per tablet. The limit is 80% of the labeled amount and shall be in accordance with the provisions.
- others shall be in accordance with the relevant provisions under the item of tablets (General rule 0101).
Content determination
operation in the dark. Take 20 tablets of this product, precision weighing, Institute of Precision weighing take appropriate amount (about 50mg equivalent to sodium ferulate), put 250ml measuring bottle, add appropriate amount of water, shake to dissolve sodium ferulate, dilute with water to scale, shake, filter, take the filtrate 5ml accurately, put it in a 100ml measuring flask, dilute it with water until the scale, and shake it well, according to UV-visible spectrophotometry (General rule 0401), the absorbance was measured at a wave of 310nm, calculated with an absorption coefficient of C10H9Na04 of 712 and multiplied by 1.167.
category
Same as sodium ferulate.
specification
50mg
storage
light shielding, sealed storage.
Last Update：2022-01-01 13:32:12
4-hydroxy-3-methoxycinnamic acid sodium salt - Sodium ferulate for injection
Authoritative Data Verified Data
This product is sterile powder or sterile lyophilized product of sodium ferulate. The content of sodium ferulate (C10H9Na04 • 2H20) shall be 90.00.0% of the label load calculated on average.
trait
This product is white or off-white crystal or crystalline powder (for bacterial powder or white to light yellow or light yellow green loose lumps or powder (for sterile lyophilized products); Odorless.
identification
take this product, according to the sodium ferulate Item Identification (1), (3) test showed the same reaction.
examination
- pH value take this product, add water to make a solution containing 50mg of ferulic acid per lml, check according to law (General rule 0631),pH value should be 6.0~7.5.
- the clarity and color of the solution take this product, and add water to make a solution containing about 20mg of sodium ferulate per 1 ml. The solution should be clear and colorless; If it is turbid, compared with the No. 1 pool degree standard solution (General rule 0902 first method), it should not be more concentrated; If the color is colored, it should not be deeper than the yellow or yellow-green No. 3 Standard Colorimetric solution (General rule 0901 first method).
- the related substances were protected from light. Take this product, add mobile phase to dissolve and dilute to make a solution containing about 0.7mg per lml as a test solution; Take lml for precision measurement, put it in a 200ml measuring flask, and dilute it to the scale with mobile phase, as a control solution. According to the method of sodium ferulate related substances. If there are impurity peaks in the chromatogram of the test solution, the sum of each impurity peak area shall not be greater than the main peak area of the control solution (0.5%).
- the moisture content of this product shall be 0832 ~ 13.0% (for sterile powder) as determined by the method for determination of moisture (General rule 16.0% first method 1). Or should not exceed 3.0% (for sterile freeze-dried products).
- pyrogen take this product, add Sterile Water for Injection to make a solution containing 5mg of sodium ferulate per lml, and check according to law (General rule 1142), and inject 3ml slowly per lkg of rabbit body weight, the requirements shall be met.
- sterility should be checked according to the method under the item of sodium ferulate, and it should be in accordance with the regulations.
- others should comply with the relevant provisions under injection (General 0102).
Content determination
operation in the dark. Take about 0.15g of the content under the item of load difference, weigh it precisely, add 20ml of glacial acetic acid to dissolve sodium ferulate, and start from "add 3ml of acetic anhydride" according to the method under the item of sodium ferulate, determination according to law. Each 1 ml of perchloric acid titration solution (0.1 mol/L) corresponds to 25.22mg of C10H9Na04 · 2H20.
category
Same as sodium ferulate.
specification
(1)0.lg (2)0.3g
storage
light shielding, sealed storage.
Last Update：2022-01-01 13:32:13
4-hydroxy-3-methoxycinnamic acid sodium salt - Reference Information
| Overview | Sodium Ferulate (SF), trade name Angelica sinensis, is the Sodium salt of ferulic acid (Ferulicacid), the chemical name is 3-methoxy-4-hydroxy acrylic acid sodium salt; It is a common effective monomer component of Angelica sinensis and Ligusticum Chuanxiong, which are commonly found in Chinese herbal medicines such as angelica sinensis, Ligusticum Chuanxiong, propolis and semen ziziphi spinosae, inhibit platelet aggregation, promote platelet deaggregation, anti-thrombosis, relieve vascular smooth muscle spasm, antioxidant and free radicals, improve membrane stability, and anti-inflammatory, analgesic, anti-fertility, regulate immune function, liver moisturizing and other pharmacological effects. Clinical mainly for the treatment of various cerebrovascular diseases, such as cerebral infarction, cerebral hemorrhage sequelae, transient cerebral ischemia; And cerebral arteriosclerosis, Head Pain, dizziness, Sleep Initiation and Maintenance Disorders, memory loss; Treatment of coronary heart disease, expansion of coronary artery, increase its blood flow, improve myocardial nutrition; Also used for leukopenia, vasculitis and benzene poisoning. |
| preparation method | synthesis of sodium ferulate sodium carbonate 53g (0.5 mol) was dissolved in 1000 of water, add ferulic acid 205g (1.05 mol), rapidly stir in boiling water bath to dissolve, while hot filter, filtrate let cool, precipitate Flake sodium ferulate crystals, filter, wash with ethanol, draw dry, it is obtained by drying below 50 ℃. The reaction scheme is shown in Figure 1. Fig.1 reaction formula for synthesis of sodium ferulate |
| pharmacological action | 1. Anti-platelet effect (1) anti-platelet aggregation effect (2) inhibition of platelet release reaction (3) inhibition of platelet adhesion reaction, inhibition of platelet aggregation by a decrease in platelet TXA2 production is similar to aspirin but less potent and durable than aspirin. However, unlike aspirin, Angelica sinensis increases platelet cAMP levels. Therefore, the two drugs in vivo in the case of inhibition of platelet aggregation in the same degree, the Angelica has no obvious effect on the production of PGI2 in the vascular wall, while aspirin has inhibitory effect on the production of vascular pgi2. This may be related to the inhibition of platelet aggregation by the metabolism of AA and also by the metabolism of cAMP. 2. Antithrombotic effect (1) antithrombotic effect Angelica sinensis intravenous injection has obvious inhibitory effect on arteriovenous shunt thrombosis in rats. (2) anticoagulant effect Angelica sinensis has a mild anticoagulant effect. 3. Analgesic effect of Angelica sinensis in patients with migraine can significantly relieve pain, and its mechanism is related to the inhibition of platelet AA metabolism and platelet 5-HT release, which may also be related to its mild analgesic effect. Antispasmodic effect of vascular smooth muscle Angelica sinensis has antispasmodic effect on spasm of isolated rabbit aortic strips induced by norepinephrine. Angelica sinensis (10-4mol/L) had a mild antagonistic effect on norepinephrine-induced spasm, but had no effect on the vasoconstrictor response induced by serotonin. The mild effect of Angelica sinensis on vascular smooth muscle may be related to the relief of migraine symptoms, but it is not the main part of the therapeutic effect of Angelica sinensis. 5. Cholagogue hepatoprotective effect 6. Antioxidant and membrane stabilizing effects (1) antioxidant and free radical scavenging effects of Angelica sinensis have a mild inhibitory effect on the erythrocyte membrane induced by oxygen free radicals, and the membrane lipid peroxidation product malondialdehyde is reduced. The mechanism of anti-lipid peroxidation of Angelica sinensis has two aspects: On the one hand, it directly scavenges free radicals and reduces the damage of free radicals to cell membrane; On the other hand, the combination of the Angelica sinensis and the membrane phosphatidylethanolamine makes the membrane less susceptible to the attack of oxygen free radicals and undergoes peroxidation. Compared with other membrane phospholipids, phosphatidylethanolamine is rich in polyunsaturated fatty acids and is most easily oxidized to produce malondialdehyde. The combination of Angelica sinensis and phosphatidylethanolamine reduced the production of malondialdehyde. (2) membrane stabilization the stability of cell membrane is related to membrane lipid peroxidation. Lipid peroxides can invade the erythrocyte membrane and cause hemolysis. The inhibition of lipid oxidation by Angelica sinensis may play a role in the stabilization of erythrocyte membrane. Angelica sinensis has a stabilizing effect on erythrocyte membrane and may be beneficial to paroxysmal nocturnal hemoglobinuria and hemolytic disease of the newborn. Regulation of immune function Angelica sinensis can enhance the function of phagocyte system. Angelicae sinensis is the effective component of Angelica sinensis. It is speculated that the blood enriching of Chinese medicine may be related to the enhancement of immune function. The enhancement of phagocytic function of Angelica sinensis is beneficial to the removal of antigen foreign bodies and the maintenance of the body's own stability. Other effects of Angelica sinensis also have anti-inflammatory effects, which have inhibitory effects on inflammatory reactions caused by various inflammatory agents, such as increased capillary permeability, tissue edema, etc. Both female and male animals have anti-fertility effects. It can also reduce the incidence of tongue cancer and precancerous lesions in rats with experimental tongue cancer; It can inhibit the infection of HIV cells, which may provide clues for the treatment of AIDS. |
| pharmacokinetics | intravenous administration, plasma protein binding rate was 20.6%, distribution half-life of 3 minutes in rats, elimination half-life of (11.46±2) minutes, rapid distribution, can pass the blood-cerebrospinal fluid barrier, mainly through the kidney excretion, the body is not easy to accumulate. The overview of sodium ferulate, preparation methods, pharmacological effects, clinical applications are Ding Hong editing. (2015-11-23) |
| Clinical application | 1. Nervous system diseases: cerebral infarction, Vertigo; 2. Cardiovascular Disease: unstable angina; 3. Urinary System Diseases: chronic renal failure (CRF), renal hypertension; 4. Diabetes: diabetes, diabetic retinopathy, diabetic nephropathy (DN);5. Respiratory diseases: pulmonary heart disease; 6. Head Pain. |
| precautions | a person had stomach pain and upper abdominal discomfort; A few people had skin allergy and drowsiness, which could disappear after drug withdrawal. Long-term use should be regularly checked platelet and liver, kidney function, abnormal should immediately stop. |
| purpose | for coronary heart disease, ischemic encephalopathy, treatment of leukopenia and thrombocytopenia |
Last Update：2024-04-09 20:45:29
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